Serveur d'exploration MERS

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SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview

Identifieur interne : 002737 ( Ncbi/Merge ); précédent : 002736; suivant : 002738

SARS-CoV-2, SARS-CoV, and MERS-COV: A comparative overview

Auteurs : Ali A. Rabaan [Arabie saoudite] ; Shamsah H. Al-Ahmed [Arabie saoudite] ; Shafiul Haque [Arabie saoudite] ; Ranjit Sah [Népal] ; Ruchi Tiwari [Inde] ; Yashpal Singh Malik [Inde] ; Kuldeep Dhama [Inde] ; M Iqbal Yatoo [Inde] ; D Katterine Bonilla-Aldana ; Alfonso J. Rodriguez-Morales [Colombie]

Source :

RBID : pubmed:32275259

Descripteurs français

English descriptors

Abstract

The recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV.

PubMed: 32275259

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pubmed:32275259

Le document en format XML

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<div type="abstract" xml:lang="en">The recent outbreak of SARS-CoV-2 that started in Wuhan, China, has now spread to several other countries and is in its exponential phase of spread. Although less pathogenic than SARS-CoV, it has taken several lives and taken down the economies of many countries. Before this outbreak, the most recent coronavirus outbreaks were the SARS-CoV and the MERS-CoV outbreaks that happened in China and Saudi Arabia, respectively. Since the SARS-CoV-2 belongs to the same family as of SARS-CoV and MERS-CoV, they share several similarities. So, this review aims at understanding the new scenario of SARS-CoV-2 outbreak and compares the epidemiology, clinical presentations, and the genetics of these coronaviruses. Studies reveal that SARS-CoV-2 is very similar in structure and pathogenicity with SARS-CoV, but the most important structural protein, i.e., the spike protein (S), is slightly different in these viruses. The presence of a furin-like cleavage site in SARS-CoV-2 facilitates the S protein priming and might increase the efficiency of the spread of SARS-CoV-2 as compared to other beta coronaviruses. So, furin inhibitors can be targeted as potential drug therapies for SARS-CoV.</div>
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<li>Arabie saoudite</li>
<li>Colombie</li>
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<name sortKey="Bonilla Aldana, D Katterine" sort="Bonilla Aldana, D Katterine" uniqKey="Bonilla Aldana D" first="D Katterine" last="Bonilla-Aldana">D Katterine Bonilla-Aldana</name>
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<name sortKey="Tiwari, Ruchi" sort="Tiwari, Ruchi" uniqKey="Tiwari R" first="Ruchi" last="Tiwari">Ruchi Tiwari</name>
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<name sortKey="Rodriguez Morales, Alfonso J" sort="Rodriguez Morales, Alfonso J" uniqKey="Rodriguez Morales A" first="Alfonso J" last="Rodriguez-Morales">Alfonso J. Rodriguez-Morales</name>
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